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Chronic laxative use, typically from the anthranoid group, causes Melanosis coli. Senna glycoside (Senna) is the main causative laxative. As the laxative travels down the intestinal tract, it remains in its inactive form until it reaches the large intestine.
Melanosis Coli is a benign reversible condition with no malignant potential.
Melanosis coli has also been found in patients who do not use laxatives or suffer from constipation, possibly because of the apoptosis of epithelial cells and their subsequent phagocytosis by macrophages of lamina propria with accumulation of lipofuscin pigment3.
Melanosis coli is a harmless condition in which the lining of the colon and rectum, which is usually pink in color, turns a shade of black or brown.
Typically seen on an endoscopy, melanosis coli is usually a dark brown or black color that can vary in darkness and intensity.
Racial melanosis of the conjunctiva should not grow. A nevus of the conjunctiva does not typically grow (except at puberty). They do not usually extend onto the cornea or develop large feeder blood vessels.
Cause. The most common cause of melanosis coli is the extended use of laxatives, and commonly anthraquinone containing laxatives such as senna, aloe vera and other plant glycosides.
The multivariate RRs associated with weekly to daily laxative use compared to never use were 0.9 (95% CI: 0.7-1.1) for total colorectal adenomatous polyps, 1.0 (95% CI: 0.7-1.5) for large adenomas and 0.8 (95% CI: 0.6-1.2) for colon adenomatous polyps only.
Oral melanosis is benign pigmentary lesion of oral mucosa. It is seen more often in smokers. Though it is clinically asymptomatic, but remains a matter of concern to rule out underlying malignancy.
Iris melanosis usually occurs in only one eye, but may occur in both eyes. Over time, the pigmented area often spreads to other parts of the iris. Iris melanosis may be a benign (harmless) condition, or it may cause secondary glaucoma if the pigmented area spreads and blocks intraocular fluid drainage.
In contrast, iris melanosis is a benign (non-cancerous) change in the iris pigment, often golden-brown in color. Iris melanosis can in some cases become iris melanoma, but not always.
Super Aloe is intended for the relief of occasional constipation. Aloe powder, the solid residue obtained by evaporating liquid aloe vera, has been shown in the research to affect regularity due to its influence on colon peristalsis, which it triggers to contract, resulting in accelerated intestinal passage.
- blood sugar (hypoglycemia)
- Burning and itching of the skin (infrequent)
- Stomach pain and cramps (high doses)
- Diarrhea, kidney problems, blood in the urine, low potassium, muscle weakness, weight loss, and heart disturbances (long-term use at high doses)
- Liver problems (rare)
The bitter latex, known as Cape aloe, is used as laxative medicine in Africa and Europe and is considered to have bitter tonic, anti-oxidant, anti-inflammatory, antimicrobial and anticancer properties.
In general, bulk-forming laxatives, also referred to as fiber supplements, are the gentlest on your body and safest to use long term. Metamucil and Citrucel fall into this category.
If you’ve been taking laxatives for a long time and can’t have a bowel movement without taking a laxative, talk with your doctor about how you can slowly stop using them. If you stop taking laxatives, over time, your colon should start moving stool normally. Your doctor may suggest using a laxative for a short time.
Stimulant laxatives are the fastest-acting, such as include aloe, cascara (Nature’s Remedy), senna compounds (Ex-Lax, Senokot), bisacodyl (Dulcolax, Correctol), and castor oil. Saline laxatives or enemas such as Fleet Phospho-Soda, milk of magnesia, and magnesium citrate.
- Coconut oil. Using your fingertip, take a very small amount of coconut oil and gently apply it evenly over your lips. …
- Rose water. Mix together two drops of rose water to six drops of honey. …
- Olive oil. …
- Cucumber juice. …
- Strawberry. …
- Almond. …
- Almond oil. …
- prescription-strength retinoids or hydroquinone.
- azelaic acid to reduce discoloration and inflammation.
- kojic acid for melasma and age spots.
- laser therapy for dark spots.
- chemical peels to help exfoliate the skin and reduce appearance of pigmentation.
Eneroth and Lundberg stated that patients are not cured of oral melanoma and that the risk of death always exists. Long periods of remission may be punctuated by sudden and silent recurrence.
Melanoma is a type of tumor, arising from the pigmented cells within the eye. In dogs, these tumors are usually benign but expansion can lead to secondary glaucoma. In cats, tumors are more likely to spread to other areas of the body. Melanosis is a non-cancerous tissue pigmentation, similar to a skin freckle.
Vulvar melanosis is characterized by asymmetrical, tan-brown to black, irregularly bordered macules of variable size on the vulvar mucosa.
You get vitamin A from the food you eat, especially vegetables that contain beta carotene, such as carrots, sweet potatoes, spinach, and peas. Since vitamin A also functions as an antioxidant, some researchers believe this vitamin, more than any other, may be the key to melanin production.
Racial melanosis is a benign, bilateral condition found most frequently in darkly pigmented people and characterized by a flat conjunctival pigmentation. These lesions are generally seen at the limbus. Racial melanosis rarely evolves into a conjunctival melanoma.
However, aside from wearing sunscreen and limiting sun exposure, you can’t lower your body’s overall melanin production. Permanent reduction isn’t possible, since melanin formation is determined by genetics. If you have hyperpigmentation, ask a doctor how to reduce melanin in the affected areas.
Research published in the Indonesian Journal of Gastroenterology Hepatology and Digestive Endoscopy suggests that 70 percent of people who frequently take anthraquinone laxatives will develop melanosis coli, often within just a few months of use. More women are diagnosed with melanosis coli than men.
What is the treatment of labial melanotic macule? Typical lesions can just be observed. Suspicious lesions, including lesions showing progressive change, should be biopsied. If treatment is requested the macules can be frozen (cryotherapy) or removed using a laser or intense pulsed light.
Aloe gel is generally safe and can be effective in treating skin conditions such as burns and psoriasis. However, avoid using aloe latex orally. Unprocessed aloe latex contains chemicals that appear to have the potential to cause cancer, and processed aloe latex might have cancer-causing compounds.
They work within 24 hours, no cramping or bloating after digesting.
Aloe works as a laxative if you swallow it. That is, it may make you poop if you haven’t been able to go. But it can cause serious stomach cramps, diarrhea, and other unpleasant symptoms, and the FDA says there isn’t enough research to be sure it’s safe.